Development of ON and OFF cholinergic amacrine cells in the human fetal retina

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Human cholinergic (ChAT) amacrine cells are first observed in the fovea at early‐gestation around fetal week (Fwk) 10, and become evident across the retina with age. Characteristic ON and OFF populations of ChAT cells with processes stratifying in separate bands in the synaptic neuropil emerge in the fovea by Fwk 11, and are present as late as mid‐gestation (Fwk 20). Previous work, however, demonstrate very few, if any, OFF ChAT‐immunoreactive cells in the adult human fovea (Rodieck & Marshak, 1992). Thus, mechanisms must act to regulate ChAT expression differentially in the ON and OFF populations as the retina matures beyond mid‐gestation.

Source: The Journal of Comparative Neurology - February 6, 2018 Category: Neurology Authors: Chi Zhang, Wan ‐Qing Yu, Akina Hoshino, Jing Huang, Fred Rieke, Thomas A. Reh, Rachel O.L. Wong Tags: Research Article Source Type: research