Effects of naloxegol on whole gut transit in opioid ‐naïve healthy subjects receiving codeine: A randomized, controlled trial

Conclusions and InferencesShort‐term administration of naloxegol (25 mg) in healthy, opioid‐naïve volunteers does not reverse the retardation of gastric, small bowel, or colonic transit induced by acute administration of codeine. Further studies with naloxegol at higher dose are warranted to assess the ability to reverse the retardation of transit caused by acute administration of codeine in opioid‐naïve subjects. Nausea, vomiting, and constipation are common adverse effects of acute or chronic opioid use. We compared the effects on pan‐gut transit of treatment with codeine, naloxegol, or combination in healthy opioid‐naïve volunteers. Short‐term administration of naloxegol (25 mg) in healthy, opioid‐naïve volunteers does not reverse the retardation of gastric, small bowel or colonic transit induced by acute administration of codeine.

http://onlinelibrary.wiley.com/resolve/doi?DOI=10.1111%2Fnmo.13298

Source: Neurogastroenterology and Motility - February 1, 2018 Category: Gastroenterology Authors: H. Halawi, P. Vijayvargiya, I. Busciglio, I. Oduyebo, D. Khemani, M. Ryks, D. Rhoten, D. Burton, L. A. Szarka, A. Acosta, M. Camilleri Tags: ORIGINAL ARTICLE Source Type: research