Colchicine Therapy and Plaque Stabilization in Patients With Acute Coronary Syndrome: A CT Coronary Angiography Study

Conclusions
Our findings suggest, for the first time, that low-dose colchicine therapy favorably modifies coronary plaque, independent of high-dose statin intensification therapy and substantial low-density lipoprotein reduction. The improvements in plaque morphology are likely driven by the anti-inflammatory properties of colchicine, as demonstrated by reductions in hsCRP, rather than changes in lipoproteins. Colchicine may be beneficial as an additional secondary prevention agent in patients post-ACS if validated in future studies.

Source: Journal of the American College of Cardiology: Cardiovascular Imaging - February 5, 2018 Category: Radiology Authors: Vaidya, K., Arnott, C., Martinez, G. J., Ng, B., McCormack, S., Sullivan, D. R., Celermajer, D. S., Patel, S. Tags: Original Research Source Type: research