Combined PET/DCE-MRI in a Rabbit Model of Atherosclerosis: Integrated Quantification of Plaque Inflammation, Permeability, and Burden During Treatment With a Leukotriene A4 Hydrolase Inhibitor

Conclusions
The authors present a comprehensive, integrated 18F-FDG PET and DCE-MRI imaging protocol to noninvasively quantify plaque inflammation, neovasculature, permeability, and burden in a rabbit model of atherosclerosis on a simultaneous PET/MRI scanner. A modest reduction was found in plaque inflammation by 18F-FDG PET in the group treated with a low dose of the LTA4H inhibitor BI691751.

Source: Journal of the American College of Cardiology: Cardiovascular Imaging - February 5, 2018 Category: Radiology Authors: Calcagno, C., Lairez, O., Hawkins, J., Kerr, S. W., Dugas, M. S., Simpson, T., Epskamp, J., Robson, P. M., Eldib, M., Bander, I., K-Raman, P., Ramachandran, S., Pruzan, A., Kaufman, A., Mani, V., Ehlgen, A., Niessen, H. G., Broadwater, J., Fayad, Z. A. Tags: Original Research Source Type: research