Effects of Melatonin on Blood Pressure, Oxidative Stress and Placental Expressions of TNF α, IL-6, VEGF and sFlt-1 in RUPP Rat Model of Preeclampsia

Preeclampsia (PE) is known as a major cause of maternal and neonatal morbidity and mortality. Maternal hypertension, proteinuria, placental dysfunction and imbalance of angiogenic factors can be observed in PE (1). The reduction in uteroplacental perfusion can cause ischemia and the ischemic placenta releases soluble factors causing maternal endothelial dysfunction and hypertension (2). These alterations also lead to an increased production of proinflammatory cytokines such as tumor necrosis factor alpha (TNF- α) and IL-6 from the placenta (3).

Source: Archives of Medical Research - February 4, 2018 Category: Research Authors: Metehan Uzun, Meryem Gencer, Hakan Turkon, Rahime Ozlem Oztopuz, Ufuk Demir, Mehmet Akif Ovali Tags: Original Article Source Type: research