Anterior cingulate cortex glutamate and its association with striatal functioning during cognitive control

Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by structural, functional and neurochemical alterations of the fronto-striatal circuits and by deficits in cognitive control. In particular, ADHD has been associated with impairments in top-down fronto-striatal glutamate-signalling. However, it is unknown whether fronto-striatal glutamate is related to cognitive control dysfunction. Here we explored whether and how anterior cingulate cortex (ACC) glutamate relates to striatal BOLD-responses during cognitive control.

Source: European Neuropsychopharmacology - February 3, 2018 Category: Psychiatry & Psychology Authors: Jilly Naaijen, David J. Lythgoe, Marcel P. Zwiers, Catharina A. Hartman, Pieter J. Hoekstra, Jan K. Buitelaar, Esther Aarts Source Type: research