Age Differences by Sex in Antiretroviral-Na ïve Participants: Pooled-Analysis from Randomized Clinical Trials

Age and sex effects on antiretroviral therapy (ART) response are not well elucidated. Our pooled-analysis of 40 randomized clinical trials measured the association of age and sex on CD4+ T cell count changes and virologic suppression using multivariable regression modeling. The average increase in CD4+ T cell count from baseline to week 48 was 17.3 cells/mm3 lower and clinically insignificant (95% CI: -30.8, -3.8) among women ≥ 50 years (n = 573) compared to women ≤ 35 years (n = 3,939). Results were similar for men.
Source: Journal of the Association of Nurses in AIDS Care - Category: Nursing Authors: Source Type: research