Personalized risk prediction of postoperative cognitive impairment – rationale for the EU-funded BioCog project

Publication date: Available online 3 February 2018 Source:European Psychiatry Author(s): G. Winterer, G. Androsova, O. Bender, D. Boraschi, F. Borchers, T.B. Dschietzig, I. Feinkohl, P. Fletcher, J. Gallinat, D. Hadzidiakos, J.D. Haynes, F. Heppner, S. Hetzer, J. Hendrikse, B. Ittermann, I.M.J. Kant, A. Kraft, A. Krannich, R. Krause, S. Kühn, G. Lachmann, S.J.T. van Montfort, A. Müller, P. Nürnberg, K. Ofosu, M. Pietsch, T. Pischon, J. Preller, E. Renzulli, K. Scheurer, R. Schneider, A.J.C. Slooter, C. Spies, E. Stamatakis, H.D. Volk, S. Weber, A. Wolf, F. Yürek, N. Zacharias Postoperative cognitive impairment is among the most common medical complications associated with surgical interventions – particularly in elderly patients. In our aging society, it is an urgent medical need to determine preoperative individual risk prediction to allow more accurate cost–benefit decisions prior to elective surgeries. So far, risk prediction is mainly based on clinical parameters. However, these parameters only give a rough estimate of the individual risk. At present, there are no molecular or neuroimaging biomarkers available to improve risk prediction and little is known about the etiology and pathophysiology of this clinical condition. In this short review, we summarize the current state of knowledge and briefly present the recently started BioCog project (Biomarker Development for Postoperative Cognitive Impairment in the Elderly), whi...
Source: European Psychiatry - Category: Psychiatry Source Type: research