Total Body Irradiation in Allogeneic Bone Marrow Transplantation Conditioning Regimens: A Review

Hematologic malignancies may require, at one point during their treatment, allogeneic bone marrow transplantation. Total body irradiation combined with chemotherapy or radiomimetic used in allogeneic bone marrow transplantation is known to be very toxic. Total body irradiation (TBI) induces immunosuppression to prevent the rejection of donor marrow. TBI is also used to eradicate malignant cells and is in sanctuary organs that are not reached by chemotherapy drugs. TBI has evolved since its introduction in the late fifties, but acute and late toxicities remain.
Source: Critical Reviews in Oncology Hematology - Category: Cancer & Oncology Authors: Source Type: research