The effects of 5-HTTLPR and BDNF Val66Met polymorphisms on neurostructural changes in major depressive disorder
The serotonin-transporter-linked polymorphic region (5-HTTLPR) and brain-derived neurotrophic factor (BDNF) Val66Met polymorphism have been implicated in the pathophysiology of major depressive disorder (MDD). We aimed to investigate the effects of genetic variants of the 5-HTTLPR and BDNF Val66Met polymorphisms and their interactions with MDD on cortical volume and white matter integrity. Ninety-five patients with MDD and 65 healthy participants aged 20 –65 years were recruited. The subjects were genotyped for the 5-HTTLPR and BDNF Val66Met polymorphisms and scanned with T1-weighted and diffusion tensor imaging.
Source: Psychiatry Research: Neuroimaging - Category: Psychiatry Authors: Kyu-Man Han, Sunyoung Choi, Aram Kim, June Kang, Eunsoo Won, Woo-Suk Tae, Young-Ku Kim, Min-Soo Lee, Byung-Joo Ham Source Type: research