Diagnostic yield of real-time polymerase chain reaction in the diagnosis of intrapartum maternal rectovaginal colonization by group B Streptococcus: a systematic review with meta-analysis

Group B streptococcus is the leading etiologic factor of neonatal sepsis. Intrapartum real-time polymerase chain reaction (RT-PCR) may allow faster and more accurate detection of maternal colonization. The aim of this study was to determine the sensitivity and specificity of RT-PCR, when compared to the reference standard culture in selective broth media, collected from rectovaginal tract from laboring women. We selected fifteen studies that included 6,368 women. Papers selection, data extraction and quality assessment were carried out by two independent researchers.

Source: Diagnostic Microbiology and Infectious Disease - February 2, 2018 Category: Microbiology Authors: Otto Henrique May Feuerschuette, Sheila Koettker Silveira, Ana Carolina Labor Cancelier, Rosemeri Maurici da Silva, Daisson Jos é Trevisol, Jefferson Ricardo Pereira Source Type: research