Laminin peptide YIGSR enhances epidermal development of skin equivalents

Since the use of animal experimentation is restricted with regard to cosmetic materials, alternative in vitro models such as skin equivalents (SEs) are needed. Laminin is one of the major non-collagenous glycoproteins. The pentapeptide YIGSR (Tyr-Ile-Gly-Ser-Arg) is a functional motif of laminin that binds to the laminin receptor. In the present study, we examined whether YIGSR could improve the reconstruction of SEs. YIGSR has no effects on monolayer cell proliferation of CCD25-Sk fibroblasts or HaCaT keratinocytes.

Source: Journal of Tissue Viability - February 2, 2018 Category: Internal Medicine Authors: Young-Yoon Kim, Hailan Li, Yu Seok Song, Hyo-Soon Jeong, Hye-Young Yun, Kwang Jin Baek, Nyoun Soo Kwon, Yong Kyoo Shin, Kyoung-Chan Park, Dong-Seok Kim Source Type: research