Identification of Host ‐Response in Cerebral Malaria Patients Using Quantitative Proteomic Analysis

Conclusions and clinical relevance: Our study signifies neuronal assault due to axonal injury, altered sodium and calcium ion channels, deregulated inflammation and demyelination as a part of host response to CM. Enhanced oxidative stress, repressed oxidative phosphorylation and demyelination of axons may contribute to the severity of the disease. Further validation of these results on a large cohort can provide leads in the development of neuroprotective therapies for CM.This article is protected by copyright. All rights reserved
Source: Proteomics. Clinical Applications - Category: Biochemistry Authors: Tags: RESEARCH ARTICLE Source Type: research