Keeping an eye on congenital disorders of O-glycosylation: a systematic literature review

AbstractCongenital disorders of glycosylation (CDG) are a rapidly growing family comprising>100 genetic diseases. Some 25 CDG are pure O-glycosylation defects. Even among this CDG subgroup, phenotypic diversity is broad, ranging from mild to severe poly-organ/system dysfunction. Ophthalmic manifestations are present in 60% of these CDG. The ophthalmic manifestations in N-glycosylation-deficient patients have been described elsewhere. The present review documents the spectrum and incidence of eye disorders in patients with pure O-glycosylation defects with the aim of assisting diagnosis and management and promoting research.
Source: Journal of Inherited Metabolic Disease - Category: Internal Medicine Source Type: research