Regenerative medicine: Cholesterol clearance restores remyelination

Nature Reviews Drug Discovery 17, 94 (2018). doi:10.1038/nrd.2018.12 Author: Katie Kingwell In progressive demyelinating diseases such as multiple sclerosis, the capacity to repair myelin damage declines with age, which limits functional recovery. Reporting in Science, Simons and colleagues have pinpointed overload of the cholesterol clearance machinery in central nervous system (CNS) macrophages as a key
Source: Nature Reviews Drug Discovery - Category: Drugs & Pharmacology Authors: Tags: Research Highlight Source Type: research