Regenerative medicine: Cholesterol clearance restores remyelination
Nature Reviews Drug Discovery 17, 94 (2018).
doi:10.1038/nrd.2018.12
Author: Katie Kingwell
In progressive demyelinating diseases such as multiple sclerosis, the capacity to repair myelin damage declines with age, which limits functional recovery. Reporting in Science, Simons and colleagues have pinpointed overload of the cholesterol clearance machinery in central nervous system (CNS) macrophages as a key
Source: Nature Reviews Drug Discovery - Category: Drugs & Pharmacology Authors: Katie Kingwell Tags: Research Highlight Source Type: research