Differential Impact of Obesity on CD69 Expression in Individuals with Bipolar Disorder and Healthy Controls

The objective of this study was to assess the moderating effects of obesity on the reduction of expression of CD69, a marker of immunosenescence. Forty euthymic patients with BD type I, aged 18 –65 years, were included in this study. The healthy comparison group consisted of 39 volunteers who had no current or lifetime history of mental disorders, no use of psychotropic medications, and no known family history of mood disorders or psychosis. Peripheral blood mononuclear cells from BD pat ients and healthy controls were collected and isolated. The cells were allowed to grow in culture and stimulated for 3 days. CD69 was marked and read in flow cytometry. We found that the lower expression of CD69 in BD patients was moderated by body mass index (BMI) in both CD4+ (RR = 0.977, 95% CI 0 .960–0.995,p = 0.013) and CD8+ cells (RR = 0.972, 95% CI 0.954 –0.990,p = 0.003). Our findings indicate that BMI could potentially influence the process of premature aging in BD.Mol Neuropsychiatry 2017;3:192 –196
Source: Molecular Neuropsychiatry - Category: Neuroscience Source Type: research