[Clinical Picture] Autoimmune hypophysitis

A 82-year-old male patient with metastatic lung adenocarcinoma presented to the outpatient clinic at the University of Texas MD Anderson Cancer Center (Houston, TX, USA) in April, 2015 with worsening fatigue, headache, dizziness, blurry vision, and nausea. He had received treatment with an immune checkpoint inhibitor, ipilimumab (an anti CTLA-4 antibody) 4 weeks before presentation. A brain MRI showed a diffuse pituitary enlargement in the T1-weighted coronal section (figure, A) and sagittal section (figure, B), with increased thickening of the pituitary stalk and enhancement of adjacent dura, suggestive of hypophysitis.

Source: The Lancet Oncology - February 1, 2018 Category: Cancer & Oncology Authors: Ecaterina Ileana-Dumbrava, Vivek Subbiah Tags: Clinical Picture Source Type: research