Total Synthesis of Aurofusarin: Studies on the Atropisomeric Stability of Bis-Naphthoquinones

AngewchemTotal Synthesis of Aurofusarin: Studies on the Atropisomeric Stability of Bis-NaphthoquinonesDr. Chao Qi, Dr. Wenyu Wang, Dr. Kyle D. Reichl, Dr. James McNeely and Prof.  Dr. John A. Porco Jr.An efficient annulation involving pyrone addition to a quinone and Dieckmann condensation was developed for rapid assembly of a γ-naphthopyrone monomeric precursor to the bis-naphthoquinone natural product aurofusarin. Dimerization was achieved through PdII-catalyzed dehydrogenative coupling. 

Source: Organometallic Current - January 31, 2018 Category: Chemistry Tags: Total synthesis Source Type: blogs