TRAP1 Regulates Autophagy in Lung Cancer Cells
Conclusions: Our results show that even though TRAP1 depletion affects both normal MRC‐5 and tumor A549 cell proliferation, inhibition of autophagy per se led to a decrease in tumor cell mass, while having a reduced effect on the normal cell line. The strategy of targeting TRAP1 in NSCLC shows future potential therapeutic applications.
This article is protected by copyright. All rights reserved.
Source: European Journal of Clinical Investigation - Category: General Medicine Authors: Ines A. Barbosa, Ignacio Vega ‐Naredo, Rute Loureiro, Ana F. Branco, Rita Garcia, Patricia M. Scott, Paulo J. Oliveira Tags: Original Article Source Type: research