Paralysis of the external popliteal sciatic nerve associated with daptomycin administration

We report a case of a 62‐year‐old man who developed external popliteal sciatic nerve paralysis after 22 days of therapy with daptomycin. What is new and conclusion: We present an uncommon and not previously reported adverse event. We have also analysed a possible alteration in a metabolic pathway (ABCB1 gene polymorphisms) that, in some patients, could explain certain drug adverse events. What is new and conclusionWe present an uncommon and not previously reported adverse event. We have also analysed a possible alteration in a metabolic pathway (ABCB1 gene polymorphisms) that, in some patients, could explain certain drug adverse events.

http://onlinelibrary.wiley.com/resolve/doi?DOI=10.1111%2Fjcpt.12666

Source: Journal of Clinical Pharmacy and Therapeutics - January 31, 2018 Category: Drugs & Pharmacology Authors: L. Villaverde Pi ñeiro, R. Rabuñal Rey, A. García Sabina, R. Monte Secades, M. J. García Pais Tags: CASE REPORT Source Type: research