Higher Ca2+ ‐sensitivity of arterial contraction in 1‐week‐old rats is due to a greater Rho‐kinase activity

ConclusionOur results suggest that the higher Ca2+‐sensitivity of arterial contraction in 1‐week‐old compared to 10‐12‐week‐old rats is due to a greater Rho‐kinase activity. Constitutively active Rho‐kinase contributes to MX‐induced contraction in 10‐12‐week‐old rats. In 1‐week‐old rats, additional Rho‐kinase activation is involved. This remodeling of the Rho‐kinase pathway is associated with its increased contribution to adrenergic arterial pressure responses.This article is protected by copyright. All rights reserved.

Source: Acta Physiologica - January 31, 2018 Category: Physiology Authors: S.V. Mochalov, N.V. Tarasova, T.V. Kudryashova, D.K. Gaynullina, V.U. Kalenchuk, A.S. Borovik, A.V. Vorotnikov, O.S. Tarasova, R. Schubert Tags: Regular Paper Source Type: research