Blockade of Treg Cell Differentiation and Function by the Interleukin ‐21–Mechanistic Target of Rapamycin Axis Via Suppression of Autophagy in Patients With Systemic Lupus Erythematosus

ConclusionIL‐21–driven mTOR activation is a pharmacologically targetable checkpoint of the deficient autophagy that underlies Treg cell dysfunction in SLE.

Source: Arthritis and Rheumatism - January 30, 2018 Category: Rheumatology Authors: Hiroshi Kato, Andras Perl Tags: Original Article Source Type: research