Reference Tissue Models in the Assessment of 11C ‐DTBZ Binding to the VMAT2 in Rat Striatum: A Test‐retest Reproducibility Study

Conclusions: To the best of our knowledge this is the first report on longitudinal studies for 11C‐DTBZ in rats using reference tissue methods. Excellent inter‐ and intra‐subject reproducibility was obtained with the multilinear reference MRTM2, suggesting this as the best method to compare longitudinal studies, whereas the SCR method had poor reliability. Logan method, on the other hand, is a method simple to compute that shows accurate reproducibility with a reasonable level of inter‐ and intra‐subject variability allowing crossover studies to follow‐up the uptake of 11C‐DTBZ in rat striatum. This article is protected by copyright. All rights reserved. Reproducibility and reliability of reference tissue‐based methods was evaluated to determine the non‐displaceable binding potential (BPND) as a quantitative measure of 11C‐DTBZ binding to the presynaptic vesicular monoamine transporter 2 (VMAT2) in rat striatum. MRTM2 and SRTM showed the best repeatability and accuracy indices followed by MRTMo, LRTM and SCR‐1.
Source: Synapse - Category: Neurology Authors: Tags: Research Article Source Type: research