Attenuation of PERK enhances glucose-stimulated insulin secretion in islets

In conclusion, partial PERK inhibition induced BiP expression in islets, increased glucose-stimulated calcium transit and islet insulin contents and enhanced GSIS, suggesting that low-dose PERK inhibitors could potentially be used to treat insulin deficiency.

Source: Journal of Endocrinology - January 30, 2018 Category: Endocrinology Authors: Kim, M. J., Min, S. H., Shin, S. Y., Kim, M. N., Lee, H., Jang, J. Y., Kim, S.-W., Park, K. S., Jung, H. S. Tags: Research Source Type: research