Methylation of Tcf712 promoter by high ‐fat diet impairs β‐cell function in mouse pancreatic islets

ConclusionAn HFD was shown to induce aberrant methylation of the Tcf7l2 promoter in mouse islets, which resulted in diminished gene expression. This study provides an evidence of the association between nutrient consumption and gene expression.

Source: Diabetes/Metabolism Research and Reviews - January 29, 2018 Category: Endocrinology Authors: Yun Hu, Ping Shi, Ke He, Yun ‐qing Zhu, Fan Yang, Min Yang, Bang‐Shun He, Xiao‐Ming Mao Tags: RESEARCH ARTICLE Source Type: research