Lactate increases myotube diameter via activation of MEK/ERK pathway in C2C12 cells

ConclusionThese observations suggest that lactate‐associated increase in the diameter of C2C12 myotubes is induced via activation of GRP81‐mediated MEK/ERK pathway. Extracellular lactate might have a positive effect on skeletal muscle size.This article is protected by copyright. All rights reserved.

Source: Acta Physiologica - January 27, 2018 Category: Physiology Authors: Yoshitaka Ohno, Akiko Oyama, Hikari Kaneko, Tatsuro Egawa, Shingo Yokoyama, Takao Sugiura, Yoshinobu Ohira, Toshitada Yoshioka, Katsumasa Goto Tags: Regular Paper Source Type: research