[Articles] Early transmissible ampicillin resistance in zoonotic Salmonella enterica serotype Typhimurium in the late 1950s: a retrospective, whole-genome sequencing study

The association between antibiotic use and selection of resistance determinants is not as direct as often presumed. Our results suggest that the non-clinical use of narrow-spectrum penicillins (eg, benzylpenicillin) might have favoured the diffusion of plasmids carrying the blaTEM-1 gene in S enterica serotype Typhimurium in the late 1950s.

Source: The Lancet Infectious Diseases - November 29, 2017 Category: Infectious Diseases Authors: Alicia Tran-Dien, Simon Le Hello, Christiane Bouchier, Fran çois-Xavier Weill Tags: Articles Source Type: research