[Comment] Tribendimidine: an alternative to praziquantel to treat human liver fluke infection?

Opisthorchis viverrini is a major foodborne trematode infection endemic to Greater Mekong subregion (GMS) countries, particularly Thailand, Laos, Cambodia, and Vietnam, with more than 10 million people in those countries infected.1 The parasite induces several hepatobiliary diseases, including cholangiocarcinoma.2 To date, the only drug of choice for the treatment of liver fluke infections has been praziquantel. Therefore, identification of new drugs to avoid development of mutations conferring resistance to praziquantel in the future is crucial.
Source: The Lancet Infectious Diseases - Category: Infectious Diseases Authors: Tags: Comment Source Type: research