A Novel Antihypertensive Peptide Identified in Thermolysin ‐Digested Rice Bran

ConclusionWe identify a novel, orally active antihypertensive peptide, LRA from the digest of rice bran protein.

Thermolysin‐digested rice bran (TRB) decreases systolic blood pressure in spontaneously hypertensive rats (SHRs). TRB show a ACE inhibitory activity in vitro and in vivo, and reduced serum troponin I levels. A novel antihypertensive peptide, LRA from TRB, is also identified, and LRA is shown to be derived from At2g28490, the vicilin‐like seed storage protein. LRA (0.25 mg kg−1) decreases systolic blood pressure after oral administration.

Source: Nahrung / Food - January 25, 2018 Category: Nutrition Authors: Naohisa Shobako, Yutaro Ogawa, Atsushi Ishikado, Kayo Harada, Etsuko Kobayashi, Hirohisa Suido, Takashi Kusakari, Mariko Maeda, Makoto Suwa, Motonobu Matsumoto, Ryuhei Kanamoto, Kousaku Ohinata Tags: RESEARCH ARTICLE Source Type: research