Targeting mutant p53 for efficient cancer therapy

Nature Reviews Cancer 18, 89 (2018). doi:10.1038/nrc.2017.109 Authors: Vladimir J. N. Bykov, Sofi E. Eriksson, Julie Bianchi & Klas G. Wiman The tumour suppressor gene TP53 is the most frequently mutated gene in cancer. Wild-type p53 can suppress tumour development by multiple pathways. However, mutation of TP53 and the resultant inactivation of p53 allow evasion of tumour cell death and rapid tumour progression. The
Source: Nature Reviews Cancer - Category: Cancer & Oncology Authors: Tags: Review Source Type: research