Ubiquitin ligases in oncogenic transformation and cancer therapy

Nature Reviews Cancer 18, 69 (2018). doi:10.1038/nrc.2017.105 Authors: Daniela Senft, Jianfei Qi & Ze'ev A. Ronai The cellular response to external stress signals and DNA damage depends on the activity of ubiquitin ligases (E3s), which regulate numerous cellular processes, including homeostasis, metabolism and cell cycle progression. E3s recognize, interact with and ubiquitylate protein substrates in a temporally and spatially regulated manner.
Source: Nature Reviews Cancer - Category: Cancer & Oncology Authors: Tags: Review Source Type: research