Dual Regulation of Decorin by Androgen and Hedgehog Signaling During Prostate Morphogenesis

Conclusion: Dcn expression and localization in the developing prostate is consistent with a primary role in organizing collagen around the developing ducts. Regulation of Dcn expression appears to be complex, involving both androgen and Hh signaling. The growth inhibitory effect of Dcn suggests a unique linkage between a structural proteoglycan and epithelial growth regulation. This may serve to coordinate two elements of the morphogenetic process: ductal growth and organization of the collagen matrix around the nascent duct. This article is protected by copyright. All rights reserved.
Source: Developmental Dynamics - Category: Molecular Biology Authors: Tags: Research Article Source Type: research