Will imaging individual raphe nuclei in males with major depressive disorder enhance diagnostic sensitivity and specificity?

Conclusions: In agreement with postmortem studies, we found higher 5‐HT1A autoreceptor binding in MDD selectively in the DRN. 5‐HT1A autoreceptor binding in the combined DRN and MRN is a better biomarker for MDD than in the raphe as a whole.

http://onlinelibrary.wiley.com/resolve/doi?DOI=10.1002%2Fda.22721

Source: Depression and Anxiety - January 1, 2018 Category: Psychiatry Authors: Rajapillai L. I. Pillai, Mengru Zhang, Jie Yang, Maura Boldrini, J. John Mann, Maria A. Oquendo, Ramin V. Parsey, Christine DeLorenzo Tags: RESEARCH ARTICLE Source Type: research