The monoclonal anti ‐CD157 antibody clone SY11B5, used for high sensitivity detection of PNH clones on WBCs, fails to detect a common polymorphic variant encoded by BST‐1

Conclusion: The failure of anti‐CD157 antibody clone SY11B5 to detect a common SNP can explain some CD157‐negative cytometric data. This provides crucial knowledge for laboratories performing PNH analyses as such results can potentially lead to false‐positive PNH interpretation. Our results confirm the importance of published PNH guidelines. This article is protected by copyright. All rights reserved.
Source: Cytometry Part B: Clinical Cytometry - Category: Molecular Biology Authors: Tags: Original Article Source Type: research