Twin DNA methylation profiling reveals flare ‐dependent interferon signature and B‐cell promoter hypermethylation in systemic lupus erythematosus

ConclusionHypomethylation of interferon‐regulated genes occurs in all major cellular compartments in SLE twins. The observed B‐cell promoter hypermethylation is a novel finding with potential significance for SLE pathogenesis.This article is protected by copyright. All rights reserved.

Source: Arthritis and Rheumatism - January 23, 2018 Category: Rheumatology Authors: Constance J Ulff ‐Møller, Fazila Asmar, Yi Liu, Anders J Svendsen, Florence Busato, Kirsten Grønbæk, Jörg Tost, Søren Jacobsen Tags: Full Length Source Type: research