Blood T Follicular Regulatory Cells / T Follicular Helper Cells ratio Marks Ectopic Lymphoid Structure Formation and PD ‐1+ICOS+ T Follicular Helper Cells Indicate Disease Activity in Primary Sjögren's Syndrome

ConclusionsBlood Tfr/Tfh ratio and PD‐1+ICOS+ Tfh cells constitute potential novel biomarkers for different features of primary SS. While blood Tfr/Tfh ratio is associated with ectopic lymphoid neogenesis, activated Tfh cells indicate disease activity.This article is protected by copyright. All rights reserved.

Source: Arthritis and Rheumatism - January 1, 2018 Category: Rheumatology Authors: Valter R Fonseca, Vasco C Rom ão, Ana Agua‐Doce, Mara Santos, Dolores López‐Presa, Ana Cristina Ferreira, João Eurico Fonseca, Luis Graca Tags: Full Length Source Type: research