The waxing and waning of antithrombotic therapy in cardiovascular disease – Where is the moon now?

Since the early 1900s, thrombosis has been known to play a major role in cardiovascular disease (CVD). Herrick1 first described total coronary occlusion in patients with sudden death or acute myocardial infarction (AMI). In the 1950s –60s, use of warfarin patients with AMI was instituted.2 By time the 1970s were almost over, significant controversy ensued over the quality of the clinical trials which weighed heavily in support for their positive findings.3–5 The first large trials of aspirin therapy began to come forward dur ing the late 1970s demonstrating that the use of aspirin would prevent recurrent AMI .

Source: Progress in Cardiovascular Diseases - January 21, 2018 Category: Cardiology Authors: Mark B. Effron, C. Michael Gibson Source Type: research