Compositional and functional variations of oral microbiota associated with the mutational changes in oral cancer
Oral cancer is a prevalent malignancy globally, with a huge majority ( ∼90%) of cases being oral squamous cell carcinoma (OSCC) [1]. In spite of advances in etiological studies and therapeutic options, the mortality of OSCC has not improved substantially over the past decades [2]. It is known that OSCC is a multifactorial neoplasm in which genetic variants interact w ith environmental triggers in the predisposition to this disease [3]. Various genetic alterations that influence cell cycle, apoptosis, and DNA repair [4] alone or in combination with external risks, including human papillomavirus (HPV) infection and habitual exposure of carcinogens, such as tobacco and alcohol use and betel nut chewing [5] have been demonstrated to contribute to the etiology and pathogenesis of oral cancer.
Source: Oral Oncology - Category: Cancer & Oncology Authors: Shun-Fa Yang, Hsien-Da Huang, Wen-Lang Fan, Yuh-Jyh Jong, Mu-Kuan Chen, Chien-Ning Huang, Chun-Yi Chuang, Yu-Lun Kuo, Wen-Hung Chung, Shih-Chi Su Source Type: research
More News: Alcoholism | Cancer | Cancer & Oncology | Carcinoma | Environmental Health | Gastroschisis Repair | Genetics | Genital Warts | Human Papillomavirus (HPV) | Oral Cancer | Skin Cancer | Smokers | Squamous Cell Carcinoma | Study