HLA class I antigen processing machinery (APM) component expression and PD-1:PD-L1 pathway activation in HIV-infected head and neck cancers

Recent research has found that human immunodeficiency virus (HIV)-infected individuals are at increased risk for developing several non-AIDS related malignancies, with a reported higher incidence of both tobacco-related and virus-related cancers [1 –5]. The higher incidence of tobacco-related cancers among HIV-infected individuals [6,7] has been attributed to the significantly higher prevalence of cigarette smoking among HIV-infected compared with HIV-uninfected individuals (40–60% vs. 17%) [8,9].

Source: Oral Oncology - December 28, 2017 Category: Cancer & Oncology Authors: Sara I. Pai, J. Jack Lee, Thomas E. Carey, William H. Westra, Soldano Ferrone, Charles Moore, Marina B. Mosunjac, Dong M. Shin, Robert L. Ferris, on behalf of the HNC SPORE HIV supplement consortium Source Type: research