Temporal and Spatial Quantification of Pain ‐ Related Small Fiber Functionality Assessed Using Laser Speckle Contrast Analysis (LASCA)

ConclusionsPain‐related small fiber functions and symptomatology (two‐in one method) can be assessed via histamine‐ or capsaicin‐ evoked axon flare responses in as little as 15 minutes. The reduction of small fiber functions are characterized by decrease in flare size/intensity at 5 minutes after stimulation and prolongation/abolishment of the latency to reach 3‐fold higher levels of baseline skin microcirculation. LASCA may be applied in clinic to aid early diagnosis, monitor disease progression, and objectively assess treatment efficacy in patients with neuropathic pain.This article is protected by copyright. All rights reserved.
Source: Pain Practice - Category: Anesthesiology Authors: Tags: Original Article Source Type: research