Improving accuracy of genomic prediction in Brangus cattle by adding animals with imputed low ‐density SNP genotypes

Summary Reliable genomic prediction of breeding values for quantitative traits requires the availability of sufficient number of animals with genotypes and phenotypes in the training set. As of 31 October 2016, there were 3,797 Brangus animals with genotypes and phenotypes. These Brangus animals were genotyped using different commercial SNP chips. Of them, the largest group consisted of 1,535 animals genotyped by the GGP‐LDV4 SNP chip. The remaining 2,262 genotypes were imputed to the SNP content of the GGP‐LDV4 chip, so that the number of animals available for training the genomic prediction models was more than doubled. The present study showed that the pooling of animals with both original or imputed 40K SNP genotypes substantially increased genomic prediction accuracies on the ten traits. By supplementing imputed genotypes, the relative gains in genomic prediction accuracies on estimated breeding values (EBV) were from 12.60% to 31.27%, and the relative gain in genomic prediction accuracies on de‐regressed EBV was slightly small (i.e. 0.87%–18.75%). The present study also compared the performance of five genomic prediction models and two cross‐validation methods. The five genomic models predicted EBV and de‐regressed EBV of the ten traits similarly well. Of the two cross‐validation methods, leave‐one‐out cross‐validation maximized the number of animals at the stage of training for genomic prediction. Genomic prediction accuracy (GPA) on the ten quantit...
Source: Journal of Animal Breeding and Genetics - Category: Genetics & Stem Cells Authors: Tags: ORIGINAL ARTICLE Source Type: research