Re: Guy et  al.: Gene therapy for Leber hereditary optic neuropathy: low-and medium-dose visual results (Ophthalmology. 2017;124:1621-1634)

We read with interest the article by Guy et  al1 about gene therapy by intravitreous, monocular injection of the AAV2-P1ND4v2 vector carrying the wild-type ND4 gene in 14 patients with Leber hereditary optic neuropathy (LHON) owing to the variant m.11778G>A in the ND4 gene. We have the following comments and concerns.
Source: Ophthalmology - Category: Opthalmology Authors: Tags: Correspondence Source Type: research