Genome-wide association study of T-wave morphology

Introduction: T wave morphology has been shown to contain different information regarding cardiac ion currents compared to the classical QT interval. Block of the HERG potassium current, IKr, gives characteristic T-wave features like flattening, skewing of the T-wave often with visible humps. Morphology Combination Score (MCS) has been developed as a better HERG block indicator then the QT interval. The aim of the study was to investigate the influence of normal genetic variation on MCS.

Source: Journal of Electrocardiology - January 1, 2018 Category: Cardiology Authors: J.K. Kanters, N. Grarup, C. Graff, J. Nielsen, A. Linneberg, T. Hansen, M.S. Olesen Source Type: research