The molecular basis for dysregulated activation of NKX2 ‐5 in vascular remodelling of systemic sclerosis

ConclusionsNKX2‐5 is genetically associated with scleroderma, pulmonary hypertension and fibrosis. Functional evidence revealed a regulatory mechanism which results in NKX2‐5 transcriptional activation in PASMC through the interaction of an upstream promoter and a novel downstream enhancer. This mechanism can act as a model for NKX2‐5 activation in cardiovascular disease characterised by vascular remodelling.This article is protected by copyright. All rights reserved.

Source: Arthritis and Rheumatism - January 17, 2018 Category: Rheumatology Authors: Athina Dritsoula, Ioannis Papaioannou, Sandra G. Guerra, Carmen Fonseca, Javier Martin, Ariane L. Herrick, David J. Abraham, Christopher P. Denton, Markella Ponticos Tags: Full Length Source Type: research