Successful treatment of rituximab ‐ and steroid‐resistant nephrotic syndrome with leukocytapheresis

We report the case of a patient with RTX‐resistant nephrotic syndrome and SRNS who was successfully treated with leukocytapheresis (LCAP). After LCAP, there was a significant reduction in proteinuria and in the total number of lymphocytes, T cells, and HLA‐DR+‐activated T cells. Moreover, the patient became sensitive to steroids and RTX. LCAP reduced circulating immune cells including activated T cells and could be effective in treating rituximab‐resistant nephrotic syndrome and SRNS and in achieving remission of proteinuria.
Source: Journal of Clinical Apheresis - Category: Hematology Authors: Tags: BRIEF REPORT Source Type: research