Diagnosis of HIV-1 infection: Performance of Xpert Qual and Geenius supplemental assays in fourth generation ELISA-reactive samples

The laboratory testing algorithm for the diagnosis of HIV infection, updated and issued in 2014 by the Centers for Disease Control and Prevention (CDC), recommends addition of an HIV-1 RNA-specific molecular assay to confirm or deny HIV infection for samples reactive in fourth generation screening assays and negative or indeterminate in the confirmation immunoassay [1]. Both the Aptima HIV-1 RNA (Gen-Probe Incorporated, San Diego, CA, USA) and the Xpert QUAL HIV-1 (XQ, Cepheid, CA, USA) qualitative HIV-1 RNA assays qualify for such cases [2,3].

Source: Journal of Clinical Virology - January 15, 2018 Category: Virology Authors: Aviya Rakovsky, Yael Gozlan, Ravit Bassal, Marina Wax, Rachel Shirazi, Mary Bakhanashvili, Zipi Kra-Oz, Sara Radian-Sadeh, Haim Ben-Zvi, Licita Schreiber, Dana Wolf, Yonat Shemer-Avni, Daniel Chemtob, Ella Mendelson, Orna Mor Tags: Short communication Source Type: research