The GPR120 agonist TUG ‐891 promotes metabolic health by stimulating mitochondrial respiration in brown fat

This study demonstrates that the GPR120 agonist TUG‐891 improves metabolic health by activation of brown fat. Mechanistically, TUG‐891 promotes respiration in brown adipocytes by stimulating GPR120‐dependent Ca2+ release and mitochondrial fragmentation, thereby activating UCP1.

Source: EMBO Molecular Medicine - January 1, 2018 Category: Molecular Biology Authors: Maaike Schilperoort, Andrea D Dam, Geerte Hoeke, Irina G Shabalina, Anthony Okolo, Aylin C Hanyaloglu, Lea H Dib, Isabel M Mol, Natarin Caengprasath, Yi ‐Wah Chan, Sami Damak, Anne Reifel Miller, Tamer Coskun, Bharat Shimpukade, Trond Ulven, Sander Kooi Tags: Research Article Source Type: research