The Role of Rhinovirus in the Pathogenesis and Acute Exacerbation of Asthma

Rhinovirus (RV) is the most common pathogen detected in the nasopharynx of individuals suffering from asthma exacerbation. Experimental data indicate that in addition to its prominent role in acute asthma exacerbation, RV may also serve as an environmental agent driving airway remodeling and bronchial hyperresponsiveness. Understanding the host-pathogen interplay, which results in both acute asthma exacerbation and the instigation of burgeoning disease, may highlight potential avenues for more effective therapeutic interventions. This review summarizes recent data as regards the relationship between RV infection, asthma exacerbation, and asthma pathogenesis.
Source: Clinical Pulmonary Medicine - Category: Respiratory Medicine Tags: Respiratory Infections/Obstructive Airways Disease Source Type: research