Von Willebrand disease among Egyptian women suffering from menorrhagia

Aim of the work The aim of the present study was to estimate the prevalence of von Willebrand disease (vWD) among Egyptian women suffering from menorrhagia and without pelvic pathology. Patients and methods This multicenter, prospective cohort study involved 1476 women who complained of menorrhagia at the outpatient clinics of five medical centers in Egypt. Only 359 were diagnosed with dysfunctional uterine bleeding without screening for bleeding disorders, which is not a routine work up among most gynecologists. Those women were tested for von Willebrand factor antigen (vWF Ag), von Willebrand factor activity (vWF Ac), complete blood count, prothrombin time, and international normalized ratio. Results Among the screened women, 17.8% (64/359) had been diagnosed with vWD. The vast majority (81%) had deficient vWF Ag (52/64), whereas only 19% (12/64) were suffering from defective function of the factor. None of our women had type III vWD. There was a significant positive correlation between vWF Ag or vWF Ac and the hemoglobin level (r=0.231 and 0.174, respectively), whereas the correlation showed a significant negative pattern between vWF Ag and international normalized ratio (r=−0.230, P
Source: Journal of Evidence-Based Women’s Health Journal Society - Category: OBGYN Tags: Original articles Source Type: research