Differential Expression and Remodeling of Transient Outward Potassium Currents in Human Left Ventricles [Original Articles]

Conclusions
Ito,f and Ito,s are differentially expressed in nonfailing human LV, contributing to regional heterogeneities in AP waveforms. Ito,f regulates notch and plateau potentials and modulates the time course and amplitude of ICa. Slowing Ito,f inactivation results in dramatic AP shortening. Remodeling of Ito,f in failing human LV subepicardial myocytes attenuates transmural differences in AP waveforms.

Source: Circulation: Arrhythmia and Electrophysiology - January 8, 2018 Category: Cardiology Authors: Johnson, E. K., Springer, S. J., Wang, W., Dranoff, E. J., Zhang, Y., Kanter, E. M., Yamada, K. A., Nerbonne, J. M. Tags: Arrhythmias, Electrophysiology, Ion Channels/Membrane Transport, Heart Failure, Remodeling Original Articles Source Type: research